Metabolic Networks Analysis using Convex Optimization
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biochemical reactions
chemical substances
convex optimization
metabolic networks analysis
metabolites concentrations
minimal knockout problem
minimal network problem
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Abstract
Metabolic networks map the biochemical reactions in a living cell to the flow of various chemical substances in the cell, which are called metabolites. A standard model of a metabolic network is given as a linear map from the reaction rates to the change in metabolites concentrations. We study two problems related to the analysis of metabolic networks, the minimal network problem and the minimal knockout problem.
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Copyright 2008 IEEE. Reprinted from: Julius, A.A.; Imielinski, M.; Pappas, G.J., "Metabolic networks analysis using convex optimization," Decision and Control, 2008. CDC 2008. 47th IEEE Conference on , vol., no., pp.762-767, 9-11 Dec. 2008 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=4739111&isnumber=4738560 This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Pennsylvania's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.