Denis F. Kinane, BDS, PhDAbdolhosseini, Mahsa2023-05-222016-03-152014-05-282016-03-15https://repository.upenn.edu/handle/20.500.14332/9405In this study we showed TLR2 CpG promoter methylation in periodontitis affected human gingival tissues and in primary human gingival epithelial cells chronically stimulated with P. gingivalis that may instigate epithelial dysbiosis that may create a unique pathogen niche in the gingival crevice and susceptibility to periodontitis.periodontitisinnate immunityTLR2 in Porphyromonas gingivalis recognitionheterogeneity in periodontal disease susceptibilityepigenetics of innate immunityDNA methylationDentistryPeriodontics and PeriodontologyDissertation/Thesis