Kimberg, Daniel Y.Coslett, H. BranchSchwartz, Myrna F.2023-05-222023-05-222007-07-012011-06-15https://repository.upenn.edu/handle/20.500.14332/8170Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxelbased approaches to mapping lesion–behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize the use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.Medicine and Health SciencesArticle