Saven, Jeffery G.2023-05-222023-05-222011-06-012016-06-19https://repository.upenn.edu/handle/20.500.14332/6110Computational and theoretical methods are advancing protein design as a means to create and investigate proteins. Such efforts further our capacity to control, design and understand biomolecular structure, sequence and function. Herein, the focus is on some recent applications that involve using theoretical and computational methods to guide the design of protein sequence ensembles, new enzymes, proteins with novel cofactors, and membrane proteins.© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/CoenzymesComputational BiologyEnzymesMembrane ProteinsProtein EngineeringProteinsCoenzymesComputational BiologyEnzymesMembrane ProteinsProtein EngineeringProteinsBiochemistryOrganic ChemistryArticle