Sawyer, Amy MWallace, Douglas MBuenaver, Luis FWatach, Alexa JBlase, AmySaconi, BrunoPatel, Sanjay RKuna, Samuel TPunjabi, Naresh M2023-05-232023-05-232020-05-282020-07-27https://repository.upenn.edu/handle/20.500.14332/41690Large-scale randomized trials of positive airway pressure (PAP) efficacy have been largely negative yet PAP adherence was notably sub-optimal across the trials. To address this limitation, evidence-based PAP adherence protocols embedded within the larger trial protocol are recommended. The complexity of such protocols will be dependent on adequacy of resources, including funding and inclusion of behavioral scientist experts on the scientific team, and trial-specific considerations (e.g., target population) and methods. Recommendations for optimizing PAP adherence in large-scale trials are set forth that address rigor and reproducibility.This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/bync-nd/3.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.obstructive sleep apneacontinuous positive airway pressurepatient compliancehealth behaviortelemedicinehealth educationcontrolled clinical trialbehavioral economicsMedicine and Health SciencesNursingOther